Breast cancer screening saves lives, study finds
Regular mammographic screening for breast cancer saves the lives of two women for every one who is given unnecessary treatment, scientists said on Wednesday, in a study which adds to a global row over screening programs.
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Skin cancer, although it seems small, can be quite deadly if it is not caught on time. As for how it develops, the cancer develops when DNA is damaged beyond repair. The cells that are damaged then grow and divide at a rate that is uncontrollable. When this damage occurs in the skin and the cells grow and divide uncontrollably, skin cancer is the result. The damaged cells will continue to multiply and that will cause a tumor.
The cancer usually develops in the epidermis, which is the outermost skin layer. That is why the skin cancer tumor is usually quite visible. This is why skin cancer is usually detectable in the early stages.
» Read more: What is Skin Cancer? What you need to know
In this study, a team led by Gosse J. Adema, Ph.D., of the Department of Tumor Immunology, at the Radboud University Nijmegen Medical Centre, the Netherlands, and colleagues assessed the role of DC-SCRIPT as a co-regulator of nuclear receptors, including estrogen receptor (ER), progesterone receptor (PR)-B, peroxisome proliferator-activated receptor gamma, and retinoic acid receptor alpha. Prognostic value was assessed in three independent cohorts of breast cancer patients.
The researchers found that DC-SCRIPT suppressed ER- and PR-mediated transcription in a ligand-dependent fashion, whereas it enhanced the activity of the other two receptors. Quantification of DC-SCRIPT mRNA expression in the three cohorts of patients revealed that this expression is an independent prognostic factor for breast cancer patients with ER- and/or PR-positive tumors, according to the authors.
» Read more: DC-SCRIPT Found to Have Prognostic Value in Breast Cancer